Magnetically Triggered Release of Entrapped Bioactive Proteins from Thermally Responsive Polymer-Coated Iron Oxide Nanoparticles for Stem-Cell Proliferation | Zendy

Matthew Walker | Zendy; Iain Will | Zendy; Andrew Pratt | Zendy; Victor Chechik | Zendy; Paul G. Genever | Zendy; Dániel Ungár | Zendy

Open Access

Magnetically Triggered Release of Entrapped Bioactive Proteins from Thermally Responsive Polymer-Coated Iron Oxide Nanoparticles for Stem-Cell Proliferation

Author(s) -

Matthew Walker,

Iain Will,

Andrew Pratt,

Victor Chechik,

Paul G. Genever,

Dániel Ungár

Publication year - 2020

Publication title -

acs applied nano materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.227

H-Index - 29

ISSN - 2574-0970

DOI - 10.1021/acsanm.0c01167

Subject(s) - nanoparticle , iron oxide nanoparticles , polymer , superparamagnetism , cell growth , chemistry , biophysics , magnetic nanoparticles , stem cell , nanotechnology , materials science , microbiology and biotechnology , biochemistry , organic chemistry , biology , physics , magnetization , quantum mechanics , magnetic field

Nanoparticles could conceal bioactive proteins during therapeutic delivery, avoiding side effects. Superparamagnetic iron oxide nanoparticles (SPIONs) coated with a temperature-sensitive polymer were tested for protein release. We show that coated SPIONs can entrap test proteins and release them in a temperature-controlled manner in a biological system. Magnetically heating SPIONs triggered protein release at bulk solution temperatures below the polymer transition. The entrapped growth factor Wnt3a was inactive until magnetically triggered release, upon which it could increase mesenchymal stem cell proliferation. Once the polymer transition will be chemically adjusted above body temperature, this system could be used for targeted cell stimulation in model animals and humans.

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