A DNA Origami-Based Chiral Plasmonic Sensing Device | Zendy

Yike Huang | Zendy; MinhKha Nguyen | Zendy; Ashwin Karthick Natarajan | Zendy; Vu Hoang Nguyen | Zendy; Anton Kuzyk | Zendy

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A DNA Origami-Based Chiral Plasmonic Sensing Device

Author(s) -

Yike Huang,

MinhKha Nguyen,

Ashwin Karthick Natarajan,

Vu Hoang Nguyen,

Anton Kuzyk

Publication year - 2018

Publication title -

acs applied materials and interfaces

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.535

H-Index - 228

eISSN - 1944-8252

pISSN - 1944-8244

DOI - 10.1021/acsami.8b19153

Subject(s) - dna origami , biosensor , nanotechnology , materials science , plasmon , aptamer , nanolithography , nanoscopic scale , optical sensing , analyte , nanostructure , optoelectronics , fabrication , medicine , chemistry , alternative medicine , pathology , biology , genetics

Accurate and reliable biosensing is crucial for environmental monitoring, food safety, and diagnostics. Spatially reconfigurable DNA origami nanostructures are excellent candidates for the generation of custom sensing probes. Here we present a nanoscale biosensing device that combines the accuracy and precision of the DNA origami nanofabrication technique, unique optical responses of chiral plasmonic assemblies, and high affinity and selectivity of aptamers. This combination enables selective and sensitive detection of targets even in strongly absorbing fluids. We expect that the presented sensing scheme can be adapted to a wide range of analytes and tailored to specific needs.

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