An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues | Zendy

Onur Bas | Zendy; Davide D’Angella | Zendy; Jeremy Baldwin | Zendy; Nathan J. Castro | Zendy; Felix M. Wunner | Zendy; Navid T. Saidy | Zendy; Stefan Kollmannsberger | Zendy; Alessandro Reali | Zendy; E. Rank | Zendy; Elena M. DeJuanPardo | Zendy; Dietmar W. Hutmacher | Zendy

Open Access

An Integrated Design, Material, and Fabrication Platform for Engineering Biomechanically and Biologically Functional Soft Tissues

Author(s) -

Onur Bas,

Davide D’Angella,

Jeremy Baldwin,

Nathan J. Castro,

Felix M. Wunner,

Navid T. Saidy,

Stefan Kollmannsberger,

Alessandro Reali,

E. Rank,

Elena M. DeJuanPardo,

Dietmar W. Hutmacher

Publication year - 2017

Publication title -

acs applied materials and interfaces

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.535

H-Index - 228

eISSN - 1944-8252

pISSN - 1944-8244

DOI - 10.1021/acsami.7b08617

Subject(s) - materials science , tissue engineering , fabrication , ultimate tensile strength , soft tissue , self healing hydrogels , biomedical engineering , composite number , composite material , material design , nanotechnology , polymer chemistry , engineering , medicine , alternative medicine , pathology

We present a design rationale for stretchable soft network composites for engineering tissues that predominantly function under high tensile loads. The convergence of 3D-printed fibers selected from a design library and biodegradable interpenetrating polymer networks (IPNs) result in biomimetic tissue engineered constructs (bTECs) with fully tunable properties that can match specific tissue requirements. We present our technology platform using an exemplary soft network composite model that is characterized to be flexible, yet ∼125 times stronger (E = 3.19 MPa) and ∼100 times tougher (W Ex = ∼2000 kJ m -3 ) than its hydrogel counterpart.

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