Constructing Tissuelike Complex Structures Using Cell-Laden DNA Hydrogel Bricks | Zendy

Yijie Wang | Zendy; Yu Shao | Zendy; Xiaozhou Ma | Zendy; Bini Zhou | Zendy; Alan FaulknerJones | Zendy; Wenmiao Shu | Zendy; Dongsheng Liu | Zendy

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Constructing Tissuelike Complex Structures Using Cell-Laden DNA Hydrogel Bricks

Author(s) -

Yijie Wang,

Yu Shao,

Xiaozhou Ma,

Bini Zhou,

Alan FaulknerJones,

Wenmiao Shu,

Dongsheng Liu

Publication year - 2017

Publication title -

acs applied materials and interfaces

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.535

H-Index - 228

eISSN - 1944-8252

pISSN - 1944-8244

DOI - 10.1021/acsami.7b01604

Subject(s) - materials science , self healing hydrogels , nanotechnology , fabrication , tissue engineering , dna , 3d printing , supramolecular chemistry , biomedical engineering , composite material , molecule , engineering , polymer chemistry , chemistry , medicine , alternative medicine , pathology , biochemistry , organic chemistry

Tissue engineering has long been a challenge because of the difficulty of addressing the requirements that such an engineered tissue must meet. In this paper, we developed a new "brick-to-wall" based on unique properties of DNA supramolecular hydrogels to fabricate three-dimensional (3D) tissuelike structures: different cell types are encapsulated in DNA hydrogel bricks which are then combined to build 3D structures. Signal responsiveness of cells through the DNA gels was evaluated and it was discovered that the gel permits cell migration in 3D. The results demonstrated that this technology is convenient, effective and reliable for cell manipulation, and we believe that it will benefit artificial tissue fabrication and future large-scale production.

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