A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth | Zendy

Constanze Lamprecht | Zendy; Mohammadreza Taale | Zendy; Ingo Paulowicz | Zendy; Hannes Westerhaus | Zendy; Carsten Grabosch | Zendy; Arnim Schuchardt | Zendy; Matthias Mecklenburg | Zendy; Martina Böttner | Zendy; Ralph Lucius | Zendy; Karl Schulte | Zendy; Rainer Adelung | Zendy; Christine SelhuberUnkel | Zendy

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A Tunable Scaffold of Microtubular Graphite for 3D Cell Growth

Author(s) -

Constanze Lamprecht,

Mohammadreza Taale,

Ingo Paulowicz,

Hannes Westerhaus,

Carsten Grabosch,

Arnim Schuchardt,

Matthias Mecklenburg,

Martina Böttner,

Ralph Lucius,

Karl Schulte,

Rainer Adelung,

Christine SelhuberUnkel

Publication year - 2016

Publication title -

acs applied materials and interfaces

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.535

H-Index - 228

eISSN - 1944-8252

pISSN - 1944-8244

DOI - 10.1021/acsami.6b00778

Subject(s) - materials science , scaffold , surface modification , ethylene glycol , extracellular matrix , nanotechnology , adhesion , cell adhesion , graphite , fibroblast , peg ratio , cell growth , biophysics , chemical engineering , biomedical engineering , in vitro , composite material , chemistry , biochemistry , medicine , finance , economics , biology , engineering

Aerographite (AG) is a novel carbon-based material that exists as a self-supportive 3D network of interconnected hollow microtubules. It can be synthesized in a variety of architectures tailored by the growth conditions. This flexibility in creating structures presents interesting bioengineering possibilities such as the generation of an artificial extracellular matrix. Here we have explored the feasibility and potential of AG as a scaffold for 3D cell growth employing cyclic RGD (cRGD) peptides coupled to poly(ethylene glycol) (PEG) conjugated phospholipids for surface functionalization to promote specific adhesion of fibroblast cells. Successful growth and invasion of the bulk material was followed over a period of 4 days.

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