Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery | Zendy

Yevhen Fatieiev | Zendy; Jonas G. Croissant | Zendy; Shahad K. Alsaiari | Zendy; Basem Moosa | Zendy; Dalaver H. Anjum | Zendy; Niveen M. Khashab | Zendy

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Photoresponsive Bridged Silsesquioxane Nanoparticles with Tunable Morphology for Light-Triggered Plasmid DNA Delivery

Author(s) -

Yevhen Fatieiev,

Jonas G. Croissant,

Shahad K. Alsaiari,

Basem Moosa,

Dalaver H. Anjum,

Niveen M. Khashab

Publication year - 2015

Publication title -

acs applied materials and interfaces

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.535

H-Index - 228

eISSN - 1944-8252

pISSN - 1944-8244

DOI - 10.1021/acsami.5b07365

Subject(s) - silsesquioxane , materials science , nanoparticle , morphology (biology) , nanotechnology , plasmid , dna , chemical engineering , polymer , composite material , biology , engineering , genetics

Bridged silsesquioxane nanocomposites with tunable morphologies incorporating o-nitrophenylene-ammonium bridges are described. The systematic screening of the sol-gel parameters allowed the material to reach the nanoscale with controlled dense and hollow structures of 100-200 nm. The hybrid composition of silsesquioxanes with 50% organic content homogeneously distributed in the nanomaterials endowed them with photoresponsive properties. Light irradiation was performed to reverse the surface charge of nanoparticles from +46 to -39 mV via a photoreaction of the organic fragments within the particles, as confirmed by spectroscopic monitorings. Furthermore, such nanoparticles were applied for the first time for the on-demand delivery of plasmid DNA in HeLa cancer cells via light actuation.

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