Mapping Cell Membrane Organization and Dynamics Using Soft Nanoimprint Lithography | Zendy

T. Sansen | Zendy; David SánchezFuentes | Zendy; Raïssa Rathar | Zendy; Adai Colom | Zendy; Fatima El Alaoui | Zendy; Julien Viaud | Zendy; M. Macchione | Zendy; Sylvain de Rossi | Zendy; Stefan Matile | Zendy; Raphaël Gaudin | Zendy; Volker Bäcker | Zendy; Adrián CarreteroGenevrier | Zendy; Laura Picas | Zendy

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Mapping Cell Membrane Organization and Dynamics Using Soft Nanoimprint Lithography

Author(s) -

T. Sansen,

David SánchezFuentes,

Raïssa Rathar,

Adai Colom,

Fatima El Alaoui,

Julien Viaud,

M. Macchione,

Sylvain de Rossi,

Stefan Matile,

Raphaël Gaudin,

Volker Bäcker,

Adrián CarreteroGenevrier,

Laura Picas

Publication year - 2020

Publication title -

acs applied materials and interfaces

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.535

H-Index - 228

eISSN - 1944-8252

pISSN - 1944-8244

DOI - 10.1021/acsami.0c05432

Subject(s) - nanopillar , materials science , membrane , nanotechnology , nanoimprint lithography , soft lithography , biological system , nanostructure , fabrication , chemistry , biology , medicine , alternative medicine , pathology , biochemistry

Membrane shape is a key feature of many cellular processes, including cell differentiation, division, migration, and trafficking. The development of nanostructured surfaces allowing for the in situ manipulation of membranes in living cells is crucial to understand these processes, but this requires complicated and limited-access technologies. Here, we investigate the self-organization of cellular membranes by using a customizable and benchtop method allowing one to engineer 1D SiO 2 nanopillar arrays of defined sizes and shapes on high-performance glass compatible with advanced microscopies. As a result of this original combination, we provide a mapping of the morphology-induced modulation of the cell membrane mechanics, dynamics and steady-state organization of key protein complexes implicated in cellular trafficking and signal transduction.

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