Investigating the Use of Layered Double Hydroxide Nanoparticles as Carriers of Metal Oxides for Theranostics of ROS-Related Diseases | Zendy

Yajun Liu | Zendy; Yuao Wu | Zendy; Run Zhang | Zendy; Jacinta Lam | Zendy; J. C. Ng | Zendy; Zhi Ping Xu | Zendy; Li Li | Zendy; Hang T. Ta | Zendy

Open Access

Investigating the Use of Layered Double Hydroxide Nanoparticles as Carriers of Metal Oxides for Theranostics of ROS-Related Diseases

Author(s) -

Yajun Liu,

Yuao Wu,

Run Zhang,

Jacinta Lam,

J. C. Ng,

Zhi Ping Xu,

Li Li,

Hang T. Ta

Publication year - 2019

Publication title -

acs applied bio materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.764

H-Index - 17

ISSN - 2576-6422

DOI - 10.1021/acsabm.9b00852

Subject(s) - cerium oxide , biocompatibility , reactive oxygen species , surface modification , nanoparticle , oxide , nanocarriers , hydroxide , nanocomposite , iron oxide , materials science , chemistry , nanotoxicology , nanotechnology , inorganic chemistry , biochemistry , metallurgy

Overproduction of reactive oxygen species (ROS) is commonly known as a key factor in the progression of many chronic inflammation diseases such as atherosclerosis and rheumatoid arthritis. In this study, a metal oxide nanodot-coated layered double hydroxide (LDH) nanocomposite is constructed for theranostics of ROS-related diseases. This is the first time that both cerium oxide and iron oxide nanoparticles (NPs) were attached on the surface of LDH NPs through electrostatic interaction via a nanoengineering approach. LDHs served as nanocarriers, cerium oxide NPs served as therapeutic agents due to the antioxidant properties, and iron oxide NPs served as magnetic resonance imaging (MRI) contrast agents. In vitro studies have demonstrated that the constructed nanocomposites have good biocompatibility, good antioxidant capacity to reduce ROS level in the cells, as well as satisfying cell imaging effect in MRI. Functionalization of LDH surface with cerium oxide NPs and iron oxide NPs allows the simultaneous therapy and diagnosis of ROS-related diseases and may also allow biodistribution tracking of the therapeutic cerium oxide NPs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research