T1- and T2-weighted Magnetic Resonance Dual Contrast by Single Core Truncated Cubic Iron Oxide Nanoparticles with Abrupt Cellular Internalization and Immune Evasion | Zendy

Bibek Thapa | Zendy; Daysi Diaz-Diestra | Zendy; Carlene Santiago-Medina | Zendy; Nitu Kumar | Zendy; Kaixiong Tu | Zendy; Juan BeltranHuarac | Zendy; Wojciech M. Jadwisienczak | Zendy; Brad R. Weiner | Zendy; Gerardo Morell | Zendy

Open Access

T₁- and T₂-weighted Magnetic Resonance Dual Contrast by Single Core Truncated Cubic Iron Oxide Nanoparticles with Abrupt Cellular Internalization and Immune Evasion

Author(s) -

Bibek Thapa,

Daysi Diaz-Diestra,

Carlene Santiago-Medina,

Nitu Kumar,

Kaixiong Tu,

Juan BeltranHuarac,

Wojciech M. Jadwisienczak,

Brad R. Weiner,

Gerardo Morell

Publication year - 2018

Publication title -

acs applied bio materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.764

H-Index - 17

ISSN - 2576-6422

DOI - 10.1021/acsabm.8b00016

Subject(s) - internalization , magnetic resonance imaging , dual mode , materials science , nanoparticle , contrast (vision) , nuclear magnetic resonance , in vivo , peg ratio , biophysics , iron oxide nanoparticles , nanotechnology , chemistry , cell , medicine , biology , computer science , biochemistry , radiology , physics , microbiology and biotechnology , finance , artificial intelligence , engineering , economics , aerospace engineering

Conventional T 1 - or T 2 -weighted single mode contrast-enhanced magnetic resonance imaging (MRI) may produce false results. Thereby, there is a need to develop dual contrast agents, T 1 - and T 2 -weighted, for more accurate MRI imaging. The dual contrast agents should possess high magnetic resonance (MR) relaxivities, targeted tumor linking, and minimum recognition by the immune system. We have developed nitrodopamine-PEG grafted single core truncated cubic iron oxide nanoparticles (ND-PEG-tNCIOs) capable of producing marked dual contrasts in MRI with enhanced longitudinal and transverse relaxivities of 32 ± 1.29 and 791 ± 38.39 mM -1 s -1 , respectively. Furthermore, the ND-PEG-tNCIOs show excellent colloidal stability in physiological buffers and higher cellular internalization in cancerous cells than in phagocytic cells, indicating the immune evasive capability of the nanoparticles. These findings indicate that tNCIOs are strong candidates for dual contrast MRI imaging, which is vital for noninvasive real-time detection of nascent cancer cells in vivo and for monitoring stem cells transplants.

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