Insulin Adsorption onto PE and PVC Tubings | Zendy

Nicolas Tokhadzé | Zendy; Meriem Sahnoune | Zendy; Julien Devémy | Zendy; Alain Dequidt | Zendy; Florent Goujon | Zendy; Philip Chennell | Zendy; Valérie Sautou | Zendy; Patrice Malfreyt | Zendy

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Insulin Adsorption onto PE and PVC Tubings

Author(s) -

Nicolas Tokhadzé,

Meriem Sahnoune,

Julien Devémy,

Alain Dequidt,

Florent Goujon,

Philip Chennell,

Valérie Sautou,

Patrice Malfreyt

Publication year - 2022

Publication title -

acs applied bio materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.764

H-Index - 17

ISSN - 2576-6422

DOI - 10.1021/acsabm.2c00029

Subject(s) - adsorption , gibbs free energy , polymer , chemical engineering , plasticizer , molecule , materials science , insulin , process (computing) , thermodynamics , chemistry , chromatography , organic chemistry , computer science , medicine , physics , engineering , endocrinology , operating system

We investigate the adsorption of insulin onto PE and PVC materials by using HPLC measurements and computer simulations. We interpret the experiments by calculating the Gibbs free energy profiles during the adsorption process. The values of free energy of adsorption show a good agreement with the experimental measurements. The adsorption of insulin onto the different materials is characterized through the conformational changes with respect to its conformation in water and the interfacial regions, which are described by specific arrangements of polymer chains, water, insulin, and plasticizer molecules.

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