MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product | Zendy

Fan Zhang | Zendy; Thomas P. Wyche | Zendy; Yanlong Zhu | Zendy; Doug R. Braun | Zendy; JiaXuan Yan | Zendy; Shaurya Chanana | Zendy; Ying Ge | Zendy; Ilia A. Guzei | Zendy; Marc G. Chevrette | Zendy; Cameron R. Currie | Zendy; Michael G. Thomas | Zendy; Scott R. Rajski | Zendy; Tim S. Bugni | Zendy

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MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product

Author(s) -

Fan Zhang,

Thomas P. Wyche,

Yanlong Zhu,

Doug R. Braun,

JiaXuan Yan,

Shaurya Chanana,

Ying Ge,

Ilia A. Guzei,

Marc G. Chevrette,

Cameron R. Currie,

Michael G. Thomas,

Scott R. Rajski,

Tim S. Bugni

Publication year - 2020

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.9b04535

Subject(s) - natural product , chemistry , moiety , stereochemistry , computational biology , combinatorial chemistry , biology

Forazoline A is a structurally complex PKS-NRPS hybrid produced by marine-derived Actinomadura sp. During the course of studies highlighting the application of IFS analysis as a powerful tool for natural products analysis, we were alerted to an earlier misinterpretation with respect to forazoline A structure elucidation. In particular, IFS reveals that forazoline A contains a thioketone moiety rarely seen in secondary metabolites and, thus, constitutes an even more intriguing structure than originally thought.

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