Open AccessNi-Catalyzed Regioselective Hydroalkoxylation of Branched 1,3-Dienes
Author(s) -
Gaël Tran,
Clément Mazet
Publication year - 2019
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.9b03511
Subject(s) - regioselectivity , chemistry , allylic rearrangement , catalysis , selectivity , ligand (biochemistry) , combinatorial chemistry , medicinal chemistry , organic chemistry , receptor , biochemistry
A highly regioselective Ni-catalyzed hydroalkoxylation of 1,3-dienes is reported. The use of a (P,N) ligand is essential in achieving high levels of selectivity. The optimized protocol operates under particularly mild conditions, it provides access to a broad range of structurally diverse allylic ethers, and tolerates a number of sensitive functional groups.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom