Selective C–H Olefination of Indolines (C5) and Tetrahydroquinolines (C6) by Pd/S,O-Ligand Catalysis | Zendy

WenLiang Jia | Zendy; Nick Westerveld | Zendy; Kit Ming Wong | Zendy; Thomas R. Morsch | Zendy; Matthijs Hakkennes | Zendy; Kananat Naksomboon | Zendy; M. Ángeles FernándezIbáñez | Zendy

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Selective C–H Olefination of Indolines (C5) and Tetrahydroquinolines (C6) by Pd/S,O-Ligand Catalysis

Author(s) -

WenLiang Jia,

Nick Westerveld,

Kit Ming Wong,

Thomas R. Morsch,

Matthijs Hakkennes,

Kananat Naksomboon,

M. Ángeles FernándezIbáñez

Publication year - 2019

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.9b03505

Subject(s) - chemistry , indoline , ligand (biochemistry) , catalysis , combinatorial chemistry , stereochemistry , organic chemistry , receptor , biochemistry

Herein, we report a highly selective C-H olefination of directing-group-free indolines (C5) and tetrahydroquinolines (C6) by Pd/S,O-ligand catalysis. In the presence of the S,O-ligand, a wide range of challenging indolines, tetrahydroquinolines, and olefins was efficiently olefinated under mild reaction conditions. The synthetic potential of this methodology was demonstrated by the efficient olefination of several indoline-based natural products.

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