One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation | Zendy

Daniel E. Latham | Zendy; Kurt Polidano | Zendy; Jonathan M. J. Williams | Zendy; Louis C. Morrill | Zendy

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One-Pot Conversion of Allylic Alcohols to α-Methyl Ketones via Iron-Catalyzed Isomerization–Methylation

Author(s) -

Daniel E. Latham,

Kurt Polidano,

Jonathan M. J. Williams,

Louis C. Morrill

Publication year - 2019

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.9b02900

Subject(s) - isomerization , chemistry , allylic rearrangement , methylation , catalysis , organic chemistry , alcohol , medicinal chemistry , combinatorial chemistry , biochemistry , gene

A one-pot iron-catalyzed conversion of allylic alcohols to α-methyl ketones has been developed. This isomerization-methylation strategy utilized a (cyclopentadienone)iron(0) carbonyl complex as precatalyst and methanol as the C1 source. A diverse range of allylic alcohols undergoes isomerization-methylation to form α-methyl ketones in good isolated yields (up to 84% isolated yield).

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