Bis(dimethylamino)phosphorodiamidate: A Reagent for the Regioselective Cyclophosphorylation of cis-Diols Enabling One-Step Access to High-Value Target Cyclophosphates | Zendy

Mahipal Yadav | Zendy; Ramanarayanan Krishnamurthy | Zendy

Open Access

Bis(dimethylamino)phosphorodiamidate: A Reagent for the Regioselective Cyclophosphorylation of cis-Diols Enabling One-Step Access to High-Value Target Cyclophosphates

Author(s) -

Mahipal Yadav,

Ramanarayanan Krishnamurthy

Publication year - 2019

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.9b02694

Subject(s) - chemistry , reagent , moiety , regioselectivity , vicinal , diol , combinatorial chemistry , molecule , polyol , protecting group , organic chemistry , stereochemistry , catalysis , alkyl , polyurethane

Bis(dimethylamino)phosphorodiamidate (BDMDAP) enables an efficient and one-pot cyclophosphorylation of vicinal cis -diol moiety of polyol-organics of biological importance without the need for protecting group chemistry and is amenable to large-scale reactions. The utility of this reagent is demonstrated through the synthesis of high-value targets such as cyclic phosphates of myo -inositol, nucleosides, metabolites, and drug molecules.

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