1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction | Zendy

Qian Wang | Zendy; Kumchok C. Mgimpatsang | Zendy; Markella Konstantinidou | Zendy; Svitlana V. Shishkina | Zendy; Alexander Dömlingꝉ | Zendy

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1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction

Author(s) -

Qian Wang,

Kumchok C. Mgimpatsang,

Markella Konstantinidou,

Svitlana V. Shishkina,

Alexander Dömlingꝉ

Publication year - 2019

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.9b02614

Subject(s) - tetrazole , chemistry , combinatorial chemistry , sequence (biology) , functional group , oxadiazole , organic chemistry , biochemistry , polymer

Easy to perform, functional group tolerant, and short syntheses of the privileged scaffold oxadiazole are highly desired. Here, a metal-free protocol for MCR-based synthesis of 2,5-disubstituted 1,3,4-oxadiazoles via a Ugi-tetrazole/Huisgen sequence was developed. Optimization and scope and limitations of this short and general sequence are described. The reaction was also successfully performed on a gram scale.

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