Synthesis of Ynolates via Double Deprotonation of Nonbrominated Esters | Zendy

Jun Sun | Zendy; Toshiya Yoshiiwa | Zendy; Takayuki Iwata | Zendy; Mitsuru Shindo | Zendy

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Synthesis of Ynolates via Double Deprotonation of Nonbrominated Esters

Author(s) -

Jun Sun,

Toshiya Yoshiiwa,

Takayuki Iwata,

Mitsuru Shindo

Publication year - 2019

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.9b02069

Subject(s) - deprotonation , chemistry , halogen , lithium (medication) , combinatorial chemistry , bearing (navigation) , organic chemistry , ion , medicine , alkyl , cartography , geography , endocrinology

Herein, we report a double deprotonation method used for the preparation of ynolates starting from nonbrominated 2,6-di- er -butylphenyl esters. The current method is superior to the previously described double lithium/halogen exchange approach because easily accessible starting materials are used. This method will be especially useful for preparation of ynolates bearing functional groups in organic synthesis.

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