Diastereoselective Intramolecular Hydride Transfer under Brønsted Acid Catalysis | Zendy

Bin Wang | Zendy; Dhika Aditya Gandamana | Zendy; Fabien Gagosz | Zendy; Shunsuke Chiba | Zendy

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Diastereoselective Intramolecular Hydride Transfer under Brønsted Acid Catalysis

Author(s) -

Bin Wang,

Dhika Aditya Gandamana,

Fabien Gagosz,

Shunsuke Chiba

Publication year - 2019

Publication title -

organic letters

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.9b00590

Subject(s) - chemistry , carbocation , hydride , brønsted–lowry acid–base theory , intramolecular force , stereocenter , catalysis , organic chemistry , combinatorial chemistry , enantioselective synthesis , hydrogen

A diastereoselective hydride transfer process has been developed under Brønsted acid-catalyzed reaction conditions using methyl ethers or acetals as hydride donors and tertiary alcohols or alkenes as precursors of carbocation. The method enables construction of complex molecules having multiple stereogenic centers from rather simple and readily available starting materials with predictable diastereoselective control.

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