Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression | Zendy

Tamam ElElimat | Zendy; Huzefa A. Raja | Zendy; Sloan Ayers | Zendy; Steven J. Kurina | Zendy; Joanna E. Burdette | Zendy; Zachary Mattes | Zendy; Robert C. Sabatelle | Zendy; Jeffrey W. Bacon | Zendy; Aaron H. Colby | Zendy; Mark W. Grinstaff | Zendy; Cedric J. Pearce | Zendy; Nicholas H. Oberlies | Zendy

Open Access

Meroterpenoids from Neosetophoma sp.: A Dioxa[4.3.3]propellane Ring System, Potent Cytotoxicity, and Prolific Expression

Author(s) -

Tamam ElElimat,

Huzefa A. Raja,

Sloan Ayers,

Steven J. Kurina,

Joanna E. Burdette,

Zachary Mattes,

Robert C. Sabatelle,

Jeffrey W. Bacon,

Aaron H. Colby,

Mark W. Grinstaff,

Cedric J. Pearce,

Nicholas H. Oberlies

Publication year - 2019

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.8b03769

Subject(s) - chemistry , propellane , cytotoxicity , stereochemistry , tropolone , ring (chemistry) , cytotoxic t cell , biochemistry , in vitro , bicyclic molecule , organic chemistry

Six fungal metabolites, of which five were new, including one (1) with a dioxa[4.3.3]propellane ring system, were discovered, identified, and structurally elucidated from Neosetophoma sp. (strain MSX50044); these compounds are similar to the bis-tropolone, eupenifeldin. Three of the meroterpenoids are potent cytotoxic agents against breast, ovarian, mesothelioma, and lung cancer cells with nanomolar IC 50 values while not inducing mitochondrial toxicity at 12.5 μM.

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