Open AccessNickel-Catalyzed Csp2–Csp3 Bond Formation via C–F Bond Activation
Author(s) -
Yee Ann Ho,
Matthias Leiendecker,
Xiangqian Liu,
Chengming Wang,
Nurtalya Alandini,
Magnus Rueping
Publication year - 2018
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.8b02351
Subject(s) - chemistry , aryl , catalysis , nickel , alkylation , alkyl , combinatorial chemistry , coupling (piping) , medicinal chemistry , organic chemistry , mechanical engineering , engineering
A nickel-catalyzed cross coupling of aryl fluorides via C-F bond activation has been developed. The alkylation method allows selective replacement of aryl fluorides by alkyl groups and enables the synthesis of diverse and otherwise difficult to access scaffolds in good yields.
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