Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides | Zendy

Paramita Mukherjee | Zendy; Cristian P. Woroch | Zendy; Leah Cleary | Zendy; Mark Rusznak | Zendy; Ryan Franzese | Zendy; Matthew R. Reese | Zendy; Joseph W. Tucker | Zendy; John M. Humphrey | Zendy; Sarah Etuk | Zendy; Sabrina C. Kwan | Zendy; Christopher W. am Ende | Zendy; Nicholas D. Ball | Zendy

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Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides

Author(s) -

Paramita Mukherjee,

Cristian P. Woroch,

Leah Cleary,

Mark Rusznak,

Ryan Franzese,

Matthew R. Reese,

Joseph W. Tucker,

John M. Humphrey,

Sarah Etuk,

Sabrina C. Kwan,

Christopher W. am Ende,

Nicholas D. Ball

Publication year - 2018

Publication title -

organic letters

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.8b01520

Subject(s) - chemistry , sulfonyl , steric effects , sulfonamide , nucleophile , yield (engineering) , lewis acids and bases , calcium , organic chemistry , combinatorial chemistry , catalysis , alkyl , materials science , metallurgy

A method using calcium triflimide [Ca(NTf 2 ) 2 ] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts a wide array of sterically and electronically diverse sulfonyl fluorides and amines into the corresponding sulfonamides in good yield.

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