Stereo- and Regiocontrolled Methylboration of Terminal Alkynes | Zendy

Oleksandr Zhurakovskyi | Zendy; Rafael M. P. Dias | Zendy; Adam Noble | Zendy; Varinder K. Aggarwal | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Stereo- and Regiocontrolled Methylboration of Terminal Alkynes

Author(s) -

Oleksandr Zhurakovskyi,

Rafael M. P. Dias,

Adam Noble,

Varinder K. Aggarwal

Publication year - 2018

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.8b01252

Subject(s) - regioselectivity , chemistry , transmetalation , stereoselectivity , terminal (telecommunication) , combinatorial chemistry , catalysis , organic chemistry , computer science , telecommunications

A scalable and operationally simple synthesis of trisubstituted alkenyl boronic esters has been achieved using a Zr-catalyzed carboalumination of terminal alkynes followed by in situ transmetalation with i-PrOBpin. The products are formed in good yields and with excellent regioselectivity and perfect stereoselectivity. The new procedure provides a significant improvement over the previously reported syntheses.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research