Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes | Zendy

Gregory L. Beutner | Zendy; Ronald CarrasquilloFlores | Zendy; Peng Geng | Zendy; Yi Hsiao | Zendy; Eric C. Huang | Zendy; Jacob M. Janey | Zendy; Kishta Katipally | Zendy; Sergei Kolotuchin | Zendy; Thomas La Porte | Zendy; Andrew Lee | Zendy; Paul C. Lobben | Zendy; Federico Lora Gonzalez | Zendy; Brendan Mack | Zendy; Boguslaw Mudryk | Zendy; Yuping Qiu | Zendy; Xinhua Qian | Zendy; Antonio Ramı́rez | Zendy; Thomas M. Razler | Zendy; Thorsten Rosner | Zendy; Zhongping Shi | Zendy; Eric M. Simmons | Zendy; Jason M. Stevens | Zendy; Jianji Wang | Zendy; Carolyn S. Wei | Zendy; Steven R. Wisniewski | Zendy; Ye Zhu | Zendy

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Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes

Author(s) -

Gregory L. Beutner,

Ronald CarrasquilloFlores,

Peng Geng,

Yi Hsiao,

Eric C. Huang,

Jacob M. Janey,

Kishta Katipally,

Sergei Kolotuchin,

Thomas La Porte,

Andrew Lee,

Paul C. Lobben,

Federico Lora Gonzalez,

Brendan Mack,

Boguslaw Mudryk,

Yuping Qiu,

Xinhua Qian,

Antonio Ramı́rez,

Thomas M. Razler,

Thorsten Rosner,

Zhongping Shi,

Eric M. Simmons,

Jason M. Stevens,

Jianji Wang,

Carolyn S. Wei,

Steven R. Wisniewski,

Ye Zhu

Publication year - 2018

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.8b01218

Subject(s) - atropisomer , chirality (physics) , chemistry , active ingredient , total synthesis , axial chirality , stereochemistry , ingredient , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , physics , chiral symmetry breaking , food science , quantum mechanics , nambu–jona lasinio model , quark , bioinformatics , biology

A strategy to prepare compounds with multiple chirality axes, which has led to a concise total synthesis of compound 1A with complete stereocontrol, is reported.

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