Manganese Catalyzed Regioselective C–H Alkylation: Experiment and Computation | Zendy

Chengming Wang | Zendy; Bholanath Maity | Zendy; Luigi Cavallo | Zendy; Magnus Rueping | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Manganese Catalyzed Regioselective C–H Alkylation: Experiment and Computation

Author(s) -

Chengming Wang,

Bholanath Maity,

Luigi Cavallo,

Magnus Rueping

Publication year - 2018

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.8b01179

Subject(s) - manganese , chemistry , carbenoid , regioselectivity , alkylation , catalysis , functional group , combinatorial chemistry , organic chemistry , rhodium , polymer

A new efficient manganese-catalyzed selective C2-alkylation of indoles via carbenoid insertion has been achieved. The newly developed C-H functionalization protocol provides access to diverse products and shows good functional group tolerance. Mechanistic and computational studies support the formation of a Mn(CO) 3 acetate complex as the catalytically active species.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research