Palladium-Catalyzed Ullmann Cross-Coupling of β-Iodoenones and β-Iodoacrylates with o-Halonitroarenes or o-Iodobenzonitriles and Reductive Cyclization of the Resulting Products To Give Diverse Heterocyclic Systems | Zendy

Faiyaz Khan | Zendy; Michael Dlugosch | Zendy; Xin Liu | Zendy; Marium Khan | Zendy; Martin G. Banwell | Zendy; Jas S. Ward | Zendy; Paul D. Carr | Zendy

Open Access

Palladium-Catalyzed Ullmann Cross-Coupling of β-Iodoenones and β-Iodoacrylates with o-Halonitroarenes or o-Iodobenzonitriles and Reductive Cyclization of the Resulting Products To Give Diverse Heterocyclic Systems

Author(s) -

Faiyaz Khan,

Michael Dlugosch,

Xin Liu,

Marium Khan,

Martin G. Banwell,

Jas S. Ward,

Paul D. Carr

Publication year - 2018

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.8b01015

Subject(s) - chemistry , palladium , catalysis , reductive elimination , derivative (finance) , coupling (piping) , coupling reaction , ullmann reaction , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , mechanical engineering , financial economics , engineering , economics

The palladium-catalyzed Ullmann cross-coupling of β-iodoenones and β-iodoacrylates such as 5 (X = I) with o-halonitroarenes and o-iodobenzonitriles including 2 affords products such as compound 7. These can be engaged in a range of reductive cyclization reactions leading to heterocyclic frameworks such as 3,4-benzomorphan derivative 43.

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