DNA-Templated N(Me)-Alkoxyamine Glycosylation | Zendy

Tommi Österlund | Zendy; Heidi Korhonen | Zendy; Pasi Virta | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

DNA-Templated N(Me)-Alkoxyamine Glycosylation

Author(s) -

Tommi Österlund,

Heidi Korhonen,

Pasi Virta

Publication year - 2018

Publication title -

organic letters

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.8b00113

Subject(s) - chemistry , glycosylation , glycosidic bond , dna , yield (engineering) , catalysis , ligation , combinatorial chemistry , biochemistry , microbiology and biotechnology , enzyme , materials science , metallurgy , biology

The potential of N(Me)-alkoxyamine glycosylation as a DNA-templated ligation has been studied. On a hairpin stem-template model, a notable rate enhancement and an increased equilibrium yield are observed compared to the corresponding reaction without a DNA catalyst. The N-glycosidic connection is dynamic at pH 5, whereas it becomes irreversible at pH 7. The N(Me)-alkoxyamine glycosylation may hence be an attractive pH controlled reaction for the assembly of DNA-based dynamic products.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research