Open AccessFormal (4 + 1)-Addition of Allenoates to o-Quinone Methides
Author(s) -
Katharina Zielke,
Mario Waser
Publication year - 2018
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.7b03906
Subject(s) - synthon , annulation , chemistry , quinone , simple (philosophy) , combinatorial chemistry , organic chemistry , catalysis , philosophy , epistemology
The first (4 + 1)-annulation of o-quinone methides with α-branched allenoates as C1 synthons has been developed. This operationally simple protocol gives access to highly functionalized dihydrobenzofurans in an unprecedented fashion with excellent diastereoselectivities and high yields.
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