Open AccessRuthenium-Catalyzed meta-Carboxylation
Author(s) -
Helen Barlow,
Christopher J. Teskey,
Michael F. Greaney
Publication year - 2017
Publication title -
organic letters
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.7b03387
Subject(s) - chemistry , ruthenium , catalysis , carboxylation , combinatorial chemistry , organic chemistry
The meta-carboxylation of arenes containing pyridine and other azine-directing groups is reported. Using carbon tetrabromide as the C1 source, ruthenium(III) trichloride catalysis enables functionalization of the arene meta-C-H position, affording carboxy methyl ester products after in situ reaction with methanol.
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