Trifluoromethylthiolation-Based Bifunctionalization of Diazocarbonyl Compounds by Rhodium Catalysis | Zendy

Marvin Lübcke | Zendy; Weiming Yuan | Zendy; Kálmán J. Szabó | Zendy

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Trifluoromethylthiolation-Based Bifunctionalization of Diazocarbonyl Compounds by Rhodium Catalysis

Author(s) -

Marvin Lübcke,

Weiming Yuan,

Kálmán J. Szabó

Publication year - 2017

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.7b02139

Subject(s) - chemistry , reagent , catalysis , rhodium , alkoxy group , reaction conditions , organic chemistry , medicinal chemistry , combinatorial chemistry , alkyl

A new Rh-catalyzed, three-component reaction for the oxytrifluoromethylthiolation of α-diazoketones was developed. The SCF 3 functionality was introduced using a stable dibenzenesulfonimide reagent under mild conditions. Alcohols, acetals, and ethers were used as the alkoxy sources. Cyclic ethers underwent a trifunctionalization reaction through the introduction of SCF 3 , OR, and N(SO 2 Ph) 2 substituents in a single step.

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