Transfer Hydrogenation of Carbonyl Derivatives Catalyzed by an Inexpensive Phosphine-Free Manganese Precatalyst | Zendy

Antoine BruneauVoisine | Zendy; Ding Wang | Zendy; Vincent Dorcet | Zendy; Thierry Roisnel | Zendy; Christophe Darcel | Zendy; JeanBaptiste Sortais | Zendy

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Transfer Hydrogenation of Carbonyl Derivatives Catalyzed by an Inexpensive Phosphine-Free Manganese Precatalyst

Author(s) -

Antoine BruneauVoisine,

Ding Wang,

Vincent Dorcet,

Thierry Roisnel,

Christophe Darcel,

JeanBaptiste Sortais

Publication year - 2017

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.7b01657

Subject(s) - chemistry , phosphine , catalysis , manganese , pyridine , transfer hydrogenation , ligand (biochemistry) , transition metal , hydrogen molecule , hydrogen , combinatorial chemistry , organic chemistry , polymer chemistry , ruthenium , biochemistry , receptor

A very simple and inexpensive catalytic system based on abundant manganese as transition metal and on an inexpensive phosphine-free bidendate ligand, 2-(aminomethyl)pyridine, has been developed for the reduction of a large variety of carbonyl derivatives with 2-propanol as hydrogen donor. Remarkably, the reaction proceeds at room temperature with low catalyst loading (down to 0.1 mol %) and exhibits a good tolerance toward functional groups. High TON (2000) and TOF (3600 h -1 ) were obtained.

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