Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides | Zendy

Watchara Srimontree | Zendy; Adisak Chatupheeraphat | Zendy; HsuanHung Liao | Zendy; Magnus Rueping | Zendy

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Amide to Alkyne Interconversion via a Nickel/Copper-Catalyzed Deamidative Cross-Coupling of Aryl and Alkenyl Amides

Author(s) -

Watchara Srimontree,

Adisak Chatupheeraphat,

HsuanHung Liao,

Magnus Rueping

Publication year - 2017

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.7b01194

Subject(s) - chemistry , alkyne , aryl , nickel , amide , catalysis , copper , coupling (piping) , combinatorial chemistry , polymer chemistry , organic chemistry , mechanical engineering , alkyl , engineering

A nickel-catalyzed deamidative cross-coupling reaction of amides with terminal alkynes as coupling partners was disclosed. This newly developed methodology allows the direct interconversion of amides to alkynes and enables a facile route for C(sp2)-C(sp) bond formation in a straightforward and mild fashion.

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