Open AccessAcetic Acid Promoted Redox Annulations with Dual C–H Functionalization
Author(s) -
Zhengbo Zhu,
Daniel Seidel
Publication year - 2017
Publication title -
organic letters
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.7b01047
Subject(s) - chemistry , surface modification , acetic acid , pyridine , redox , alkyl , tetrahydroisoquinoline , dual role , combinatorial chemistry , dual (grammatical number) , stereochemistry , organic chemistry , art , literature
Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with 2-alkylquinoline-3-carbaldehydes as well as the corresponding 4-alkyl isomers and pyridine analogues. These processes involve dual C-H bond functionalization. Acetic acid is used as a cosolvent and acts as the sole promoter of these transformations.
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