B(C6F5)3-Catalyzed Michael Reactions: Aromatic C–H as Nucleophiles | Zendy

Wu Li | Zendy; Thomas Werner | Zendy

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B(C₆F₅)₃-Catalyzed Michael Reactions: Aromatic C–H as Nucleophiles

Author(s) -

Wu Li,

Thomas Werner

Publication year - 2017

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.7b00720

Subject(s) - nucleophile , chemistry , regioselectivity , michael reaction , catalysis , lewis acids and bases , medicinal chemistry , substrate (aquarium) , reaction conditions , organic chemistry , oceanography , geology

The Michael reaction is a widely used reaction for the C-C coupling of electron-poor olefins and C(sp 3 )-H pronucleophiles. Herein we report the Michael reaction between alkenes and aromatic as well as heteroaromatic compounds as aromatic C(sp 2 )-H nucleophiles under mild conditions. The reaction is catalyzed by readily available Lewis acidic B(C 6 F 5 ) 3 and proceeds with high regioselectivity for a wide substrate scope.

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