Open AccessRuthenium-Catalyzed Synthesis of β-Hydroxyamides from β-Ketonitriles in Water
Author(s) -
Rebeca González-Fernández,
Pascale Crochet,
Victorio Cadierno
Publication year - 2016
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.6b03172
Subject(s) - ruthenium , chemistry , catalysis , tandem , sodium formate , formate , transfer hydrogenation , combinatorial chemistry , organic chemistry , materials science , composite material
An unprecedented hydration/transfer hydrogenation tandem process for the catalytic conversion of β-ketonitriles into synthetically useful β-hydroxyamides in water has been developed, making use of the ruthenium(II) complex [RuCl 2 (η 6 -p-cymene){P(4-C 6 H 4 F) 2 Cl}] in combination with sodium formate.
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