Free-Radical Carbocyanation of Cyclopropenes: Stereocontrolled Access to All-Carbon Quaternary Stereocenters in Acyclic Systems | Zendy

Nitin S. Dange | Zendy; Frédéric Robert | Zendy; Yannick Landais | Zendy

Open Access

Free-Radical Carbocyanation of Cyclopropenes: Stereocontrolled Access to All-Carbon Quaternary Stereocenters in Acyclic Systems

Author(s) -

Nitin S. Dange,

Frédéric Robert,

Yannick Landais

Publication year - 2016

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.6b03163

Subject(s) - stereocenter , chemistry , cyclopropane , ring (chemistry) , quaternary carbon , carbon fibers , stereochemistry , base (topology) , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , computer science , algorithm , mathematical analysis , mathematics , composite number

Free-radical carbocyanation of cyclopropenes offers straightforward access to tetrasubstituted cyclopropanes in satisfying yields with moderate diastereoselectivity. The incorporation of various functional groups on the cyclopropane ring allows a subsequent base-mediated ring-opening reaction leading to functionalized acyclic systems having an all-carbon quaternary stereocenter.

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