Open AccessEnantioselective Synthesis of 4- and 6-Azaindolines by a Cation-Directed Cyclization
Author(s) -
Alan Lamb,
Peter D. Davey,
Russell W. Driver,
Amber L. Thompson,
Martin D. Smith
Publication year - 2016
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.6b02744
Subject(s) - chemistry , enantioselective synthesis , combinatorial chemistry , catalysis , 2 aminopyridine , stereochemistry , organic chemistry
Functionalized 4- and 6-azaindolines are accessible with high levels of enantioselectivity by the cation-directed cyclization of aminopyridine-derived imines via phase-transfer catalysis. The extension of this methodology to diastereoselective cyclizations is also described.
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