Palladium-Assisted Removal of a Solubilizing Tag from a Cys Side Chain To Facilitate Peptide and Protein Synthesis | Zendy

Suman Kumar Maity | Zendy; Guy Mann | Zendy; Muhammad Jbara | Zendy; Shay Laps | Zendy; Guy Kamnesky | Zendy; Ashraf Brik | Zendy

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Palladium-Assisted Removal of a Solubilizing Tag from a Cys Side Chain To Facilitate Peptide and Protein Synthesis

Author(s) -

Suman Kumar Maity,

Guy Mann,

Muhammad Jbara,

Shay Laps,

Guy Kamnesky,

Ashraf Brik

Publication year - 2016

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.6b01442

Subject(s) - chemistry , palladium , side chain , native chemical ligation , peptide , ligation , combinatorial chemistry , chemical ligation , biochemistry , organic chemistry , chemical synthesis , catalysis , microbiology and biotechnology , in vitro , biology , polymer

Reversible attachment of solubilizing tags to hydrophobic peptides to facilitate their purification and ligation is an essential yet challenging task in chemical protein synthesis. The efficient palladium-assisted removal of the solubilizing tag linked to the Cys side chain is reported. The strategy was applied for the efficient preparation of histone protein H4 from two fragments via one-pot operation of ligation, removal of the solubilizing tag, and desulfurization.

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