Open AccessRedox-Annulation of Cyclic Amines and β-Ketoaldehydes
Author(s) -
Weijie Chen,
Daniel Seidel
Publication year - 2016
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.6b00151
Subject(s) - chemistry , annulation , intramolecular force , redox , acetic acid , isoquinoline , combinatorial chemistry , mannich reaction , tetrahydroisoquinoline , organic chemistry , catalysis
Benzo[a]quinolizine-2-one derivatives are readily assembled from 1,2,3,4-tetrahydroisoquinoline and β-ketoaldehydes by means of a new intramolecular redox-Mannich process. These reactions are promoted by simple acetic acid and are thought to involve azomethine ylides as reactive intermediates.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom