Para-Selective Halogenation of Nitrosoarenes with Copper(II) Halides | Zendy

Angela van der Werf | Zendy; Nicklas Selander | Zendy

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Para-Selective Halogenation of Nitrosoarenes with Copper(II) Halides

Author(s) -

Angela van der Werf,

Nicklas Selander

Publication year - 2015

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.5b03198

Subject(s) - halogenation , chemistry , nitrobenzene , aniline , regioselectivity , halide , bromide , copper , chloride , organic chemistry , combinatorial chemistry , catalysis

The para-selective direct bromination and chlorination of nitrosoarenes with copper(II) bromide and chloride is reported. Under mild reaction conditions, a range of halogenated arylnitroso compounds are obtained in moderate to good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of a one-pot procedure to obtain the corresponding para-halogenated aniline- and nitrobenzene derivatives.

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