Open AccessCopper-Catalyzed Cross-Coupling of Allylboronic Acids with α-Diazoketones
Author(s) -
Arindam Das,
Dong Wang,
MarieCharlotte Belhomme,
Kálmán J. Szabó
Publication year - 2015
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.5b02285
Subject(s) - chemistry , catalysis , copper , coupling (piping) , combinatorial chemistry , organic chemistry , metallurgy , materials science
Copper-catalyzed cross-coupling of substituted allylboronic acids with α-diazoketones was studied. This allylation reaction is highly regioselective, providing the branched allylic product. The process involves creation of a new C(sp(3))-C(sp(3)) bond by retaining the keto functional group of the α-diazoketone precursor.
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