Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers | Zendy

İdris Karakaya | Zendy; David N. Primer | Zendy; Gary A. Molander | Zendy

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Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers

Author(s) -

İdris Karakaya,

David N. Primer,

Gary A. Molander

Publication year - 2015

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.5b01463

Subject(s) - chemistry , catalysis , transmetalation , iridium , aryl , coupling (piping) , coupling reaction , combinatorial chemistry , dual role , dual (grammatical number) , photoredox catalysis , photochemistry , organic chemistry , photocatalysis , mechanical engineering , art , alkyl , literature , engineering

Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of Csp(3) hybridized organotrifluoroborates. Cross-coupling of α-alkoxymethyltrifluoroborates with aryl and heteroaryl bromides has been demonstrated by employing dual catalysis with a combination of an iridium photoredox catalyst and a Ni cross-coupling catalyst. The resulting method enables the alkoxymethylation of diverse (hetero)arenes under mild, room-temperature conditions.

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