Synthesis of Fluorosugar Reagents for the Construction of Well-Defined Fluoroglycoproteins | Zendy

Míriam Salvadó | Zendy; Beatrice Amgarten | Zendy; Sergio Castillón | Zendy; Gonçalo J. L. Bernardes | Zendy; Omar Boutureira | Zendy

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Synthesis of Fluorosugar Reagents for the Construction of Well-Defined Fluoroglycoproteins

Author(s) -

Míriam Salvadó,

Beatrice Amgarten,

Sergio Castillón,

Gonçalo J. L. Bernardes,

Omar Boutureira

Publication year - 2015

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.5b01259

Subject(s) - chemistry , reagent , glycosyl , stereoselectivity , glycosylation , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , biochemistry

2-Deoxy-2-fluoroglycosyl iodides are privileged glycosyl donors for the stereoselective preparation of 1-Nu-β-fluorosugars, which are useful reagents for chemical site-selective protein glycosylation. Ready access to such β-fluorosugars enables the mild and efficient construction of well-defined fluoroglycoproteins.

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