Open AccessEnantioselective Synthesis of 3-Methyleneindan-1-ols via a One-Pot Allylboration–Heck Reaction of 2-Bromobenzaldehydes
Author(s) -
Ewen D. D. Calder,
Andrew Sutherland
Publication year - 2015
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.5b01047
Subject(s) - chemistry , enantioselective synthesis , heck reaction , catalysis , organic chemistry , reaction conditions , combinatorial chemistry , palladium
A novel, one-pot allylboration-Heck reaction of 2-bromobenzaldehydes has been developed for the general and efficient synthesis of 3-methyleneindan-1-ols. Modification of the one-pot procedure to include chiral Brønsted acid catalyzed allylation has allowed the preparation of these building blocks in high enantioselectivity and excellent yields.
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