Synergistic Copper/Enamine Catalysis for the Regio-, Stereo-, and Enantioselective Intermolecular α-Addition of Aldehydes to Allenamides | Zendy

Rémi Blieck | Zendy; Sébastien Lemouzy | Zendy; Arie van der Lee | Zendy; Marc Taillefer | Zendy; Florian Monnier | Zendy

Open Access

Synergistic Copper/Enamine Catalysis for the Regio-, Stereo-, and Enantioselective Intermolecular α-Addition of Aldehydes to Allenamides

Author(s) -

Rémi Blieck,

Sébastien Lemouzy,

Arie van der Lee,

Marc Taillefer,

Florian Monnier

Publication year - 2021

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.1c03477

Subject(s) - enantioselective synthesis , chemistry , enamine , intermolecular force , catalysis , copper , amine gas treating , organic chemistry , combinatorial chemistry , molecule

We herein describe an intermolecular enantioselective α-addition of aldehydes to allenamides using a dual copper/enamine catalytic system. Highly enantioselective addition of aldehydes was obtained thanks to secondary amine catalysts. The process was found to be highly regio-, stereo-, and enantioselective under mild conditions.

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