Synthesis of α-Amino Acid N-Carboxyanhydrides | Zendy

Guillaume Laconde | Zendy; Muriel Amblard | Zendy; Jean Martínez | Zendy

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Synthesis of α-Amino Acid N-Carboxyanhydrides

Author(s) -

Guillaume Laconde,

Muriel Amblard,

Jean Martínez

Publication year - 2021

Publication title -

organic letters

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.1c02224

Subject(s) - chemistry , reagent , phosgene , yield (engineering) , amino acid , epimer , halogen , combinatorial chemistry , organic chemistry , biochemistry , alkyl , materials science , metallurgy

A simple phosgene- and halogen-free method for synthesizing α-amino acid N -carboxyanhydrides (NCAs) is described. The reaction between Boc-protected α-amino acids and T3P reagent gave the corresponding NCA derivatives in good yield and purity with no detectable epimerization. The process is safe, is easy-to-operate, and does not require any specific installation. It generates nontoxic, easy to remove byproducts. It can apply to the preparation of NCAs for the on-demand on-site production of either little or large quantities.

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