Au(I)-Catalyzed Oxidative Functionalization of Yndiamides | Zendy

Zixuan Tong | Zendy; Olivia L. Garry | Zendy; Philip CameronSmith | Zendy; Yubo Jiang | Zendy; Steven J. Mansfield | Zendy; Edward A. Anderson | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Au(I)-Catalyzed Oxidative Functionalization of Yndiamides

Author(s) -

Zixuan Tong,

Olivia L. Garry,

Philip CameronSmith,

Yubo Jiang,

Steven J. Mansfield,

Edward A. Anderson

Publication year - 2021

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.1c01625

Subject(s) - chemistry , steric effects , regioselectivity , nucleophile , surface modification , catalysis , oxidative phosphorylation , combinatorial chemistry , functional group , nitrogen atom , nitrogen , stereochemistry , group (periodic table) , organic chemistry , biochemistry , polymer

Yndiamides, underexplored cousins of ynamides, offer rich synthetic potential as doubly nitrogenated two carbon building blocks. Here we report a gold-catalyzed oxidative functionalization of yndiamides to access unnatural amino acid derivatives, using a wide range of nucleophiles as a source of the amino acid side chain. The transformation proceeds under mild conditions, is highly functional group tolerant, and displays excellent regioselectivity through subtle steric differentiation of the yndiamide nitrogen atom substituents.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research