Short and Modular Synthesis of Substituted 2-Aminopyrroles | Zendy

Raquel DianaRivero | Zendy; Beate Halsvik | Zendy; Fernando GarcíaTellado | Zendy; David Tejedor | Zendy

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Short and Modular Synthesis of Substituted 2-Aminopyrroles

Author(s) -

Raquel DianaRivero,

Beate Halsvik,

Fernando GarcíaTellado,

David Tejedor

Publication year - 2021

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.1c01345

Subject(s) - domino , chemistry , isomerization , cascade reaction , tandem , modular design , combinatorial chemistry , dig , reaction conditions , organic chemistry , catalysis , programming language , computer science , materials science , computer security , composite material

We herein describe a simple and metal-free domino methodology to synthesize 2-aminopyrroles from alkynyl vinyl hydrazides. The domino reaction involves a novel propargylic 3,4-diaza-Cope rearrangement and a tandem isomerization/5-exo-dig N-cyclization reaction. By using this approach, a number of 2-aminopyrroles with diverse substituents have been prepared.

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