Open AccessFormal Enone α-Arylation via I(III)-Mediated Aryl Migration/Elimination
Author(s) -
Bruna S. Martins,
Daniel Kaiser,
Adriano Bauer,
Irmgard Tiefenbrunner,
Nuno Maulide
Publication year - 2021
Publication title -
organic letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.94
H-Index - 239
eISSN - 1523-7060
pISSN - 1523-7052
DOI - 10.1021/acs.orglett.1c00251
Subject(s) - enone , chemistry , enol , aryl , silylation , formal synthesis , transformation (genetics) , combinatorial chemistry , stereochemistry , catalysis , organic chemistry , biochemistry , alkyl , gene
A formal enone α-arylation is described. This metal-free transformation relies on the I(III)-mediated skeletal reorganization of silyl enol ethers and features mild conditions, good yields, and high stereoselectivities for β-substituted enones.
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