Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents | Zendy

Claire Andersen | Zendy; Vincent Ferey | Zendy; Marc Daumas | Zendy; Patrick Bernardelli | Zendy; Amandine Guérinot | Zendy; Janine Cossy | Zendy

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Copper-Catalyzed Cross-Coupling between Alkyl (Pseudo)halides and Bicyclopentyl Grignard Reagents

Author(s) -

Claire Andersen,

Vincent Ferey,

Marc Daumas,

Patrick Bernardelli,

Amandine Guérinot,

Janine Cossy

Publication year - 2020

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.0c02115

Subject(s) - halide , chemistry , alkyl , reagent , catalysis , primary (astronomy) , copper , coupling (piping) , grignard reagent , organic chemistry , coupling reaction , combinatorial chemistry , medicinal chemistry , metallurgy , physics , materials science , astronomy

The development of a copper-catalyzed cross-coupling between primary and secondary (pseudo)halides and bicyclopentyl Grignard reagents is reported. Highly strained bicyclopentanes can be cross-coupled with a large panel of primary alkyl mesylates and secondary alkyl iodides. The catalytic system is simple and cheap, and the reaction is general and chemoselective.

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