SuFEx Activation with Ca(NTf2)2: A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides | Zendy

Subham Mahapatra | Zendy; Cristian P. Woroch | Zendy; Todd W. Butler | Zendy; Sabri. Carneiro | Zendy; Sabrina C. Kwan | Zendy; Samuel R. Khasnavis | Zendy; Junha Gu | Zendy; Jason K. Dutra | Zendy; Beth C. Vetelino | Zendy; Justin Bellenger | Zendy; Christopher W. am Ende | Zendy; Nicholas D. Ball | Zendy

Open Access

SuFEx Activation with Ca(NTf₂)₂: A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides

Author(s) -

Subham Mahapatra,

Cristian P. Woroch,

Todd W. Butler,

Sabri. Carneiro,

Sabrina C. Kwan,

Samuel R. Khasnavis,

Junha Gu,

Jason K. Dutra,

Beth C. Vetelino,

Justin Bellenger,

Christopher W. am Ende,

Nicholas D. Ball

Publication year - 2020

Publication title -

organic letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.94

H-Index - 239

eISSN - 1523-7060

pISSN - 1523-7052

DOI - 10.1021/acs.orglett.0c01397

Subject(s) - chemistry , dabco , sulfamide , sulfonyl , combinatorial chemistry , organic chemistry , catalysis , alkyl

A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.

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